Dyslipidemia management requires a multifaceted approach that includes both lifestyle modifications and pharmacotherapy. The primary goal of treatment is to reduce LDL-C levels to lower cardiovascular (CV) risk. Additionally, some patients may require other therapies to address residual CV risk associated with elevated triglycerides or elevated lipoprotein(a) [Lp(a)].
The 2018 AHA/ACC/Multisociety cholesterol guideline emphasized the importance of lowering LDL-C as the primary treatment target. This guideline focuses on populations where statin therapy has been proven to lower both LDL-C and CV event risk, known as the four statin benefit groups. In 2022, the ACC published an Expert Consensus Decision Pathway for nonstatin therapy, recommending specific LDL-C thresholds for all four statin benefit groups, rather than just two as per the 2018 guideline. While statin therapy is effective in reducing CV risk and LDL-C levels, some patients may require additional nonstatin therapies to achieve optimal LDL-C reduction. Several nonstatin therapies, including ezetimibe, bempedoic acid, PCSK9 monoclonal antibodies, and inclisiran, are available and effective in further lowering LDL-C. This program will review these LDL-C lowering therapies and their optimal use to improve patient outcomes.
Even when LDL-C is reduced to recommended levels, patients with elevated triglycerides or Lp(a) remain at increased risk for CV events. Clinicians should be aware of the evidence linking elevated triglycerides and Lp(a) with CV events, as well as the latest innovations and outcomes data related to current and emerging drug therapies for these conditions. This session will review outcomes data on the use of omega-3 fatty acids in patients with elevated triglycerides. Additionally, it will cover two medications in phase III trials, pelacarsen and olpasiran, which lower Lp(a) in conjunction with statin therapy.
Planning Committee Disclosure - No relevant relationships
All members of the 小蝌蚪视频. planning committee have provided disclosures of financial relationships with ineligible organizations and any relevant non-financial relationships prior to planning content for this activity. None of the committee members had relevant financial relationships with ineligible companies or other potentially biasing relationships to disclose to learners. For speaker disclosures, please see the faculty biography.
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For Planning Committee disclosures, please see the statement above. For speaker disclosures, please see the faculty biography.
Earn up to 2.0 CE hours. Please see below, for more details, as credit amounts vary by state and profession.
This self-study program offers 120 instructional minutes of pharmacology content which is designed to qualify for 2.0 contact hours toward your pharmacology requirement.
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小蝌蚪视频. is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. This activity was originally recorded on 12/12/2024. It was last reviewed on 10/25/2024 and is valid until 10/25/2027. You are required to successfully complete and submit a post-test prior to receiving a certificate of completion.
小蝌蚪视频. designates this enduring material for a maximum of 2.0 AMA PRA Category 1 Credit(s)™. Physicians should only claim credit commensurate with the extent of their participation in the activity.
AAPA accepts certificates of participation for educational activities certified for AMA PRA Category 1 Credit™ from organizations accredited by ACCME such as 小蝌蚪视频. Physician assistants may receive a maximum of 2.0 hours for completing this self-study program. This activity was originally recorded on 12/12/2024. It was last reviewed on 10/25/2024 and is valid until 10/25/2027.
小蝌蚪视频. is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. 小蝌蚪视频. designates this enduring material for a maximum of 2.0 AMA PRA Category 1 Credit(s)™.
This self-study activity qualifies for 2.0 continuing education clock hours as required by many national, state and local licensing boards and professional organizations. Save your activity advertisement and certificate of completion, and contact your own board or organization for specific requirements.
| File type | File name | Number of pages | |
|---|---|---|---|
| Manual - Lipid Logic: An Update on Current and Future Pharmacologic Approaches to Dyslipidemia Management (3 MB) | 42 Pages | Available after Purchase |
Joseph Saseen, PharmD, BCPS, BCACP, CLS, FASHP, FCCP, FAPhA, MNLA is Associate Dean for Clinical Affairs and Professor of Clinical Pharmacy and a Professor of Family Medicine at the University Anschutz Medical Campus. He has responsibilities for enhancing the school’s clinical enterprise, further developing sustainable clinical service models, advocating for advancing the practice of pharmacy in the state of Colorado, and manages strategic international relationships.
Dr. Saseen is a clinical pharmacist who focuses on cardiovascular risk reduction and population health. His scholarly work includes over two hundred peer-reviewed publications and book chapters. He is a past president of the National Lipid Association (NLA). Dr. Saseen is a fellow of the American College of Clinical Pharmacy, American Society of Health-system Pharmacists, American Pharmacists Association, and the American Heart Association. He is a Master of the NLA and is certified as a Clinical Lipid Specialist. He was an author of the 2018 AHA/ACC/Multisociety cholesterol management guideline, the 2022 NLA Statin Intolerance Scientific Statement, and the 2024 NLA/American Geriatrics Society Managing Hypercholesterolemia in Adults Aged 75 Years and Older Without a History of ASCVD Expert Consensus Statement.
Speaker Disclosures:
Financial: Joseph Saseen has employment relationships with the University of Colorado Anschutz Medical Campus, the University of Colorado Skaggs School of Pharmacy and Pharmaceutical Sciences, and the University of Colorado Department of Family Medicine. He serves on a safety monitoring board that is sponsored by Amgen. Joseph Saseen receives grants from CU Medicine Medicaid Upper Payment Limit, Rocky Mountain Coordinated Care Network, American Society of Health-System Pharmacists Foundation Pharmacy Residency Research Grant Program, and the SSPPS Seed Grant Program for Covid-19 Research. He receives a speaking honorarium from 小蝌蚪视频. All relevant financial relationships with ineligible organizaitons have been mitigated.
Non-financial: Joseph Saseen is a member of the American Society of Health-Systems Pharmacists, the American College of Clinical Pharmacy, the American Association of Colleges of Pharmacy, the Colorado Pharmacists Society, the National Lipid Association, the American Pharmacists Association, and the International Pharmaceutical Federation.
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